What is the Origin of Pregnenolone Sulfate Memory?

Pregnenolone is synthesized from cholesterol and is the precursor to virtually all other steroid hormones, including androgens, estrogens, and cortisol; PregS is its sulfated form. Its designation as a neurosteroid stems from its high concentration in the brain and its rapid, non-genomic effects on neuronal excitability. The "Memory" component highlights the specific cognitive domain where its physiological influence is most pronounced.

What is the Mechanism of Pregnenolone Sulfate Memory?

The mechanism involves PregS's direct interaction with neurotransmitter receptors, acting as a neuro-excitatory agent by facilitating the function of the NMDA receptor, which is critical for long-term potentiation and synaptic strengthening. Simultaneously, its antagonistic action at the inhibitory GABA-A receptor further enhances neuronal excitability and communication. This dual action supports the necessary neural activity required for efficient encoding and consolidation of memories.

Pregnenolone Sulfate Memory ∞ Area

Pregnenolone Sulfate Memory

Meaning

Pregnenolone Sulfate Memory refers to the specific, critical role of the neurosteroid pregnenolone sulfate (PregS) in enhancing cognitive processes, particularly those related to memory formation, retrieval, and synaptic plasticity within the central nervous system. PregS is a sulfated metabolite of pregnenolone, acting as a potent positive allosteric modulator of the NMDA receptor and an antagonist of the GABA-A receptor. Clinical research focuses on its potential to support cognitive function and protect against age-related memory decline.