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Pregnenolone Sulfate Function

Meaning

Pregnenolone sulfate function refers to the specific neuroactive and endocrine roles of the sulfated form of pregnenolone, a major neurosteroid and precursor to virtually all other steroid hormones. Unlike its unsulfated counterpart, pregnenolone sulfate does not readily cross the blood-brain barrier but is synthesized de novo in the brain and acts as a positive allosteric modulator of NMDA receptors. Its primary function is to influence neuronal excitability, enhance memory, and modulate mood and anxiety, demonstrating a direct and significant impact on central nervous system function.