What is the Origin of Pregnenolone Protocols?

The term combines the name of the steroid molecule, "pregnenolone," which is derived from its role in the synthesis of progestogens (related to pregnancy), with "protocols," signifying a systematic plan of treatment. The use of pregnenolone in clinical practice emerged from the understanding of the steroidogenic cascade in the adrenal glands and gonads.

What is the Mechanism of Pregnenolone Protocols?

Pregnenolone is synthesized from cholesterol, primarily in the adrenal glands, liver, and brain. Its clinical use aims to provide a substrate to rebalance the downstream production of other vital steroid hormones, acting as a 'mother hormone.' As a neurosteroid, it also directly modulates GABA-A and NMDA receptors in the brain, which contributes to its potential effects on mood, memory, and sleep architecture, independent of its conversion to other steroids.

Pregnenolone Protocols ∞ Area

Pregnenolone Protocols

Meaning

Clinical strategies or therapeutic regimens involving the controlled administration of pregnenolone, a crucial endogenous neurosteroid and the precursor molecule for virtually all other steroid hormones, including cortisol, DHEA, testosterone, and estrogen. These protocols are typically implemented to support adrenal function, modulate the steroidogenesis pathway, and potentially address cognitive or mood symptoms related to hormonal decline. Dosing and monitoring are highly individualized.