What is the Origin of Pregnenolone Neurogenesis?

The concept is rooted in neuroendocrinology and neuroscience, following the discovery that steroid hormones and their precursors, known as neurosteroids, are synthesized de novo within the brain itself. Research established pregnenolone's direct, non-genomic effects on neuronal growth and survival, independent of its conversion to other sex hormones. This mechanism is central to understanding and supporting brain health in the context of hormonal aging.

What is the Mechanism of Pregnenolone Neurogenesis?

Pregnenolone acts as a potent neurotrophic factor, influencing neurogenesis by modulating the activity of NMDA receptors and promoting the expression of key growth factors like Brain-Derived Neurotrophic Factor (BDNF). It enhances the proliferation and differentiation of neural stem cells into mature, functional neurons, a process crucial for structural plasticity. Furthermore, it contributes to synaptic maintenance and protection against excitotoxicity, ensuring the long-term integrity of vital neural circuits.

Pregnenolone Neurogenesis

Meaning

Pregnenolone Neurogenesis describes the critical process where the neurosteroid pregnenolone, or its key metabolites, actively promotes the creation of new functional neurons in the adult brain, primarily in regions like the hippocampus. This is a vital mechanism for maintaining cognitive flexibility, memory formation, and systemic resilience against neurodegenerative processes. Pregnenolone’s direct role in neurogenesis highlights its importance beyond its function as a primary hormonal precursor.