What is the Origin of Pregnenolone Cognitive Support?

The term is rooted in endocrinology and neurosteroid research, highlighting pregnenolone's position at the beginning of the steroidogenesis cascade. The recognition of its potent, direct action within the central nervous system established its unique role in 'Cognitive Support,' separate from its downstream metabolites like DHEA or progesterone.

What is the Mechanism of Pregnenolone Cognitive Support?

Pregnenolone and its sulfate metabolite, Pregnenolone Sulfate (Preg-S), exert their effects by interacting with multiple neurotransmitter systems. Preg-S acts as a positive allosteric modulator of the NMDA receptor, enhancing excitatory signaling crucial for learning and memory. Concurrently, it also modulates GABA-A receptors, contributing to balanced neural excitability. This dual action supports synaptic plasticity and neuronal resilience, providing a fundamental layer of cognitive maintenance.

Pregnenolone Cognitive Support

Meaning

Pregnenolone Cognitive Support refers to the neuro-modulatory and neuro-protective effects of the steroid hormone pregnenolone, often called the “mother hormone,” on various aspects of brain function. Pregnenolone is a crucial neurosteroid that is synthesized locally in the brain, where it acts independently of its role as a precursor to other steroids. This support manifests as enhanced memory, improved mood stability, and protection against age-related cognitive decline.