What is the Origin of Pregnenolone Brain Function?

This concept stems from the discovery of neurosteroids, a class of steroids synthesized in the brain that act locally to influence neuronal function, distinct from their peripheral endocrine roles. Pregnenolone's significance was recognized early due to its position as the precursor to all other steroid hormones.

What is the Mechanism of Pregnenolone Brain Function?

Pregnenolone and its metabolites primarily function as positive allosteric modulators of the NMDA receptor and GABAA receptors, crucial for learning and calming pathways, respectively. By modulating these receptors, pregnenolone helps maintain the delicate balance between excitation and inhibition, supporting memory encoding and providing a buffer against stress-induced neurotoxicity.

Pregnenolone Brain Function

Meaning

The critical role of the neurosteroid pregnenolone, synthesized both in the adrenal glands and directly within the central nervous system, in modulating neuronal excitability, synaptic plasticity, and overall cognitive health. Pregnenolone and its sulfate ester act as potent modulators of various neurotransmitter receptors, influencing mood, memory consolidation, and stress response. Its presence is vital for maintaining the brain’s youthful functional capacity.