Question 1

What is the Meaning of Pregnanediol?

Accepted Answer

Pregnanediol, chemically known as 5β-pregnane-3α,20α-diol, is the primary inactive, end-stage metabolite of the steroid hormone progesterone. It is produced through the metabolic breakdown of progesterone, mainly in the liver, and is subsequently conjugated and excreted in the urine. Measuring pregnanediol levels in a clinical setting provides a reliable, integrated assessment of the body's overall progesterone production and metabolic clearance over time.

Question 2

What is the Origin of Pregnanediol?

Accepted Answer

The compound was first isolated and identified in the 1930s as a major excretory product in the urine of pregnant women, which is how it acquired its name. Its quantitative measurement became a standard method for indirectly monitoring corpus luteum function and placental progesterone production before direct assays for progesterone were widely available.

Question 3

What is the Mechanism of Pregnanediol?

Accepted Answer

Progesterone is metabolized via reduction reactions involving 5α- and 5β-reductase enzymes, followed by hydroxysteroid dehydrogenases. The resulting pregnanediol is then conjugated, typically with glucuronic acid, which increases its water solubility. This conjugation mechanism facilitates its efficient elimination from the body via the renal system, serving as a biological mechanism for deactivating and clearing excess progesterone.

Pregnanediol

Meaning

Origin

Mechanism

What Are the Advantages of Urine Hormone Analysis for Long-Term Monitoring?

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