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Prefrontal Cortex Control Override

Meaning

Prefrontal Cortex Control Override describes the temporary or chronic failure of the brain’s executive control center, the prefrontal cortex (PFC), to successfully inhibit powerful, immediate urges for hedonic rewards, particularly in the context of highly palatable food consumption. This override signifies a functional imbalance where the impulsive, limbic system drives circumvent the PFC’s role in planning, delayed gratification, and adherence to long-term goals. It is a core neurobiological component of loss-of-control eating.