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Prefrontal Cortex

Meaning

The Prefrontal Cortex (PFC) is the most anterior region of the frontal lobe of the brain, recognized as the executive control center responsible for complex cognitive behaviors, personality expression, decision-making, and moderating social behavior. This region is intimately connected to the endocrine system, as it contains numerous receptors for steroid hormones like estrogen and testosterone, which modulate its function. Optimal hormonal status is critical for maintaining the cognitive resilience and emotional regulation governed by the PFC, particularly during aging.