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Prefrontal-Amygdala Connectivity

Meaning

Prefrontal-Amygdala Connectivity refers to the functional and structural communication pathways linking the prefrontal cortex (PFC), the brain’s center for executive function and cognitive control, with the amygdala, the primary region for processing emotions, fear, and arousal. This connectivity is a critical biological substrate for emotional regulation, stress tolerance, and social behavior. Its strength and efficiency are profoundly modulated by circulating hormones, including cortisol and testosterone.