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Predictive Dosing Models

Meaning

Predictive Dosing Models are sophisticated mathematical and computational algorithms utilized in clinical practice to estimate the optimal initial dose and subsequent adjustments of a therapeutic agent, such as a hormone, for an individual patient. These models integrate patient-specific data, including body weight, age, renal and hepatic function, genetic polymorphisms from pharmacogenomic analysis, and baseline hormone levels, to forecast the drug’s pharmacokinetic and pharmacodynamic behavior. Employing these models moves hormone replacement therapy from empirical trial-and-error to a data-driven, precision science, enhancing safety and efficacy from the outset.