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Precursor Shoring

Meaning

Precursor Shoring is a targeted nutritional and clinical strategy involving the deliberate, often high-dose, supplementation of biochemical precursors to ensure adequate raw material availability for downstream synthesis of essential hormones, neurotransmitters, or other vital molecules. The term “shoring” suggests reinforcing the foundation or supply line of a metabolic pathway to prevent a rate-limiting step due to substrate deficiency. This approach is frequently employed when there is evidence of a functional bottleneck in a specific biosynthetic pathway.