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Precocious Metabolic Signaling

Meaning

Precocious Metabolic Signaling refers to the premature activation or heightened sensitivity of metabolic pathways and hormonal axes at an inappropriately early stage of development, often due to environmental or nutritional factors. This early signaling, particularly involving insulin and growth factors, can accelerate maturation processes, lead to rapid weight gain, and set a permanent, adverse metabolic setpoint. Clinically, it is associated with early pubertal development and an increased lifelong risk for metabolic syndrome, type 2 diabetes, and cardiovascular disease.