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Preclinical Pathology Reduction

Meaning

Preclinical Pathology Reduction is a preventative clinical strategy focused on identifying and mitigating subclinical, asymptomatic biological abnormalities that precede the manifestation of overt, diagnosable disease. This involves using advanced biomarkers and imaging to detect early-stage pathological processes, such as silent inflammation, early insulin resistance, or sub-threshold amyloid accumulation, and implementing targeted interventions. The objective is to halt or reverse these subtle changes before they cross the clinical threshold and become symptomatic conditions, such as neurodegeneration or cardiovascular disease.