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Preclinical Decline Assessment

Meaning

Preclinical Decline Assessment is a proactive diagnostic strategy focused on identifying subtle, non-symptomatic shifts in crucial hormonal and metabolic biomarkers that precede the onset of overt clinical disease or significant functional impairment. This assessment seeks to detect early, subclinical deviations from optimal youthful ranges, such as minor HPA axis blunting or subtle decreases in free hormone indices and their metabolites. Early detection allows for the implementation of preventative interventions before pathology is fully established and irreversible tissue damage occurs.