A highly individualized, data-driven clinical approach to healthspan extension that utilizes an individual’s unique genetic, biochemical, and environmental profile to design targeted therapeutic and lifestyle interventions against the fundamental mechanisms of aging. This paradigm moves away from one-size-fits-all anti-aging protocols toward molecularly precise strategies for longevity. It represents the most advanced frontier in proactive health management.
Origin
This term is a specialized application of the broader Precision Medicine initiative, which was initially focused on oncology and disease treatment. For aging, the focus shifts to primary prevention and the optimization of biological function. The concept is fueled by advancements in genomics, proteomics, and advanced diagnostic technologies that allow for deep, personalized biological profiling.
Mechanism
The mechanism involves identifying an individual’s specific “Aging Pathophysiology Mapping” by analyzing biomarkers of the Nine Hallmarks of Aging, such as genomic instability, mitochondrial dysfunction, and altered intercellular communication. Based on this profile, interventions—which may include targeted hormone modulation, specific peptide therapies, or senolytic agents—are precisely selected and dosed to correct the individual’s unique molecular dysfunctions, thereby slowing the rate of biological decline.
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