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Precision Dosing Vulnerability

Meaning

Precision dosing vulnerability describes the inherent risk of suboptimal therapeutic outcomes or adverse events that arises when an individualized dosing regimen fails to account for a patient’s unique and dynamic pharmacokinetic and pharmacodynamic parameters. This vulnerability is particularly relevant in hormonal health, where small variations in metabolism, receptor sensitivity, or adherence can significantly alter systemic hormone levels and clinical response. It underscores the challenge of achieving true precision and the necessity of continuous monitoring and dose titration.