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Precision Dosing Regimen

Meaning

A Precision Dosing Regimen (PDR) is a therapeutic plan where the dose of an active compound, often a hormone or a modulator, is determined by integrating individual physiological data points—including baseline levels, receptor sensitivity, and metabolic clearance rate—rather than relying on standardized population averages. The regimen is designed to achieve a specific, pre-defined molecular effect with the minimum necessary dose. PDRs aim to maximize therapeutic benefit while actively minimizing off-target effects and negative feedback suppression. It is the antithesis of one-size-fits-all prescribing.