A highly personalized and data-intensive clinical approach to longevity that utilizes advanced molecular diagnostics, such as genomics, epigenetics, and proteomics, to create bespoke interventions that target an individual’s specific biological aging mechanisms. This ‘precision’ methodology moves away from generalized protocols to address unique cellular and endocrine dysfunctions. The goal is to maximize healthspan by accurately measuring and therapeutically correcting the individual hallmarks of aging.
Origin
This term is a synthesis of the concepts of Precision Medicine and Biogerontology, reflecting the clinical adoption of high-resolution biological data. The term emphasizes the scientific rigor and personalization required to effectively intervene in the complex, multifactorial process of aging. It represents the future of evidence-based longevity medicine.
Mechanism
The mechanism involves using epigenetic clocks and other biomarkers to pinpoint the rate and cause of an individual’s biological aging. Interventions are then precisely tailored to modulate specific longevity pathways, such as mTOR, sirtuins, and AMPK, based on the patient’s unique genetic and metabolic profile. By addressing aging at the molecular level with high specificity, this approach aims to restore cellular function and reverse measurable biological age.
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