A comprehensive, proactive clinical and lifestyle strategy focused on preventing the progression from impaired glucose tolerance or pre-diabetes to overt Type 2 Diabetes Mellitus. Mitigation involves targeted interventions to restore insulin sensitivity, normalize blood glucose levels, and address underlying metabolic dysfunction and hormonal imbalances. This preventative approach is essential for long-term healthspan extension.
Origin
This term is rooted in preventative medicine and public health, addressing the growing prevalence of metabolic syndrome and its precursors. Mitigation refers to the actions taken to reduce the severity and likelihood of a negative health outcome. Pre-diabetic describes the state of elevated but not yet diagnostic blood sugar.
Mechanism
The strategy primarily focuses on improving the body’s response to insulin through dietary changes, such as time-restricted eating and reducing refined carbohydrate intake, and regular physical activity. These interventions enhance glucose uptake by muscle cells and reduce the demand on pancreatic beta-cells. By consistently maintaining healthy postprandial glucose excursion control and reducing visceral adiposity, the underlying hormonal and cellular drivers of insulin resistance are reversed.
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