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PR-A and PR-B Receptors

Meaning

PR-A and PR-B Receptors are the two major, functionally distinct isoforms of the Progesterone Receptor, a nuclear receptor protein that acts as a ligand-activated transcription factor to mediate the diverse biological effects of the hormone progesterone. Both isoforms are critical for reproductive health, bone density, and central nervous system function, yet they often exert different, sometimes opposing, effects on gene expression. Understanding the relative expression and activation of PR-A and PR-B is vital for interpreting the cellular response to progesterone therapy. They are generated from the same gene but possess unique regulatory domains.