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PPAR Alpha Promoter

Meaning

The PPAR Alpha Promoter is a specific DNA sequence located upstream of the Peroxisome Proliferator-Activated Receptor alpha (PPARα) gene, which serves as the binding site for transcription factors to initiate the gene’s expression. PPARα is a nuclear receptor protein that functions as a master regulator of lipid metabolism, fatty acid oxidation, and energy homeostasis, particularly in the liver, heart, and skeletal muscle. The activity of this promoter is crucial because it dictates the cellular concentration of the PPARα protein, thereby controlling the body’s capacity to process fats and maintain metabolic health. Variations in this promoter sequence can contribute to individual differences in metabolic response and disease susceptibility.