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PPARγ

Meaning

PPARγ, or Peroxisome Proliferator-Activated Receptor gamma, is a nuclear receptor protein that functions as a ligand-activated transcription factor, playing a central role in regulating gene expression related to adipogenesis, lipid metabolism, and insulin sensitivity. It is predominantly expressed in adipose tissue, where it drives the differentiation of pre-adipocytes into mature, metabolically healthy fat cells. As a master regulator of metabolic function, its activity is a key therapeutic target for improving insulin resistance and managing Type 2 diabetes. Modulating PPARγ activity is crucial for maintaining systemic energy balance and preventing ectopic fat accumulation.