What is the Origin of Postnatal Neurogenesis Control?

This concept extends the discovery of adult neurogenesis, specifying the 'Postnatal' period to encompass the continuous process of new neuron generation in the mature brain. 'Control' emphasizes the regulatory influence of both intrinsic and extrinsic factors on this vital regenerative process.

What is the Mechanism of Postnatal Neurogenesis Control?

Control is exerted through a dynamic interplay of transcription factors, neurotransmitter activity, and endocrine signals. Glucocorticoids, for instance, can exert a suppressive effect on neural precursor cell survival, while factors like BDNF and sex steroids, such as estrogen, actively promote their proliferation and differentiation. This hormonal regulation acts as a critical interface, connecting the body's overall physiological state to the brain's capacity for structural adaptation and plasticity.

Postnatal Neurogenesis Control ∞ Area

Postnatal Neurogenesis Control

Meaning

The complex, systemic regulatory mechanisms that dictate the rate, location, and ultimate cellular fate of new neuron formation in the brain following birth, extending throughout the entire adult lifespan. This control system ensures that the production and integration of new neurons are appropriately balanced with environmental stimuli and the body’s systemic health status, a balance critically influenced by circulating hormones.