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Postmenopausal Hormone Therapy Discontinuation

Meaning

Postmenopausal Hormone Therapy Discontinuation refers to the cessation of prescribed exogenous estrogen, with or without progestogen, previously administered to manage symptoms or mitigate health risks associated with the menopausal transition. This clinical decision is often guided by current treatment guidelines, which recommend the use of hormone therapy for the shortest duration necessary to achieve treatment goals. Discontinuation can lead to a recurrence of vasomotor symptoms, urogenital atrophy, and psychological changes as the body adjusts to the withdrawal of exogenous hormonal support. A structured, individualized plan is often employed to minimize the re-emergence of menopausal symptoms.