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Postmenopausal Cognition

Meaning

Postmenopausal Cognition refers to the collective changes in cognitive function, including memory, executive function, and processing speed, that are observed in women following the cessation of ovarian estrogen production. The decline in circulating estradiol significantly impacts neural circuits, as estrogen is a potent neurosteroid that modulates synaptic plasticity, cerebral blood flow, and neurotransmitter systems throughout the brain. While some cognitive changes are a normal part of aging, the abrupt hormonal shift during menopause can lead to a distinct constellation of subjective and objective cognitive symptoms, often described as “brain fog.” Clinical attention to this area focuses on mitigating the impact of estrogen withdrawal on neural health and supporting long-term cognitive resilience.