Clinical methodologies aimed at preserving or restoring the efficiency of cellular maintenance, energy production, and tissue turnover following the sustained withdrawal of ovarian estrogen production. This focus addresses the metabolic deceleration often seen after the final menstrual period. We seek to optimize cellular function independent of ovarian support.
Origin
This concept arises from endocrinology’s understanding of estrogen’s pleiotropic effects on cellular metabolism, particularly concerning mitochondrial health and lipid handling. The postmenopausal state presents a unique metabolic challenge.
Mechanism
Efficiency is supported by optimizing remaining hormonal drivers, such as thyroid hormone signaling and appropriate growth hormone release patterns. Furthermore, interventions often target the preservation of mitochondrial integrity and reduction of chronic, low-grade inflammation, which impedes cellular housekeeping processes. This sustained support maintains functional output despite reduced steroid hormone availability.
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