What is the Origin of Postmenopausal Androgen Decline?

This term is rooted in reproductive endocrinology and gerontology, stemming from studies that mapped the hormonal changes across a woman's lifespan. While estrogen decline is the hallmark of menopause, the significant reduction in androgen production by both the ovaries and adrenal glands defines this specific decline. The recognition of the clinical impact of low androgens led to the development of targeted therapies.

What is the Mechanism of Postmenopausal Androgen Decline?

The mechanism involves the near-complete cessation of androgen production by the postmenopausal ovary, which was a significant source of testosterone and androstenedione. Although the adrenal glands continue to produce precursor androgens like DHEA and androstenedione, the overall circulating level drops substantially. This reduction in androgenic signaling affects numerous tissues, including the brain, bone, and muscle, contributing to various postmenopausal symptoms.

Postmenopausal Androgen Decline ∞ Area

Postmenopausal Androgen Decline

Meaning

Postmenopausal Androgen Decline describes the physiological reduction in the production and circulating levels of androgens, primarily testosterone and androstenedione, that occurs in women following the cessation of ovarian function. This decline is a natural consequence of aging and menopause, often contributing to symptoms such as reduced libido, diminished energy, and loss of lean muscle mass. Clinical assessment is necessary to determine if the decline warrants therapeutic intervention.