What is the Origin of Postbiotic Therapeutics?

The term is a modern refinement in the field of microbiome science, following the development of probiotics (live organisms) and prebiotics (substrate for organisms). "Postbiotic" signifies the biologically active substances produced after the microbial metabolic process. This shift in focus is driven by the desire for stability, precision, and safety in microbial-derived interventions.

What is the Mechanism of Postbiotic Therapeutics?

Postbiotics function by directly interacting with host cells, including immune cells and colonocytes, often through pattern recognition receptors or specific signaling pathways. For instance, short-chain fatty acids, a class of postbiotics, can regulate gene expression and fortify the intestinal barrier. Administering these compounds directly provides a means to bypass potential colonization issues and rapidly deliver functional molecules that support metabolic and hormonal balance.

Postbiotic Therapeutics ∞ Area

Postbiotic Therapeutics

Meaning

Postbiotic Therapeutics involves the clinical application of non-viable microbial cells, their cellular components, or their specific metabolites that confer a health benefit to the host. These therapeutic agents, which are the functional end-products of microbial fermentation, are administered to modulate the host’s physiological processes, particularly those related to immunity and metabolic health. This approach offers a targeted method to leverage the benefits of the microbiome without introducing live organisms.