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Postbiotic Signaling Molecules

Meaning

Postbiotic Signaling Molecules are the beneficial, biologically active compounds produced by the resident gut microbiota as a byproduct of fermentation, which then exert direct, positive effects on host physiology, including endocrine function. These molecules, distinct from the microbes themselves or the prebiotics they consume, act as critical mediators in the gut-hormone axis. Examples include specific short-chain fatty acids or secondary bile acids that communicate systemic regulatory messages. We recognize these metabolic outputs as therapeutic agents.