Postbiotic Metabolites are the beneficial, biologically active compounds generated as a direct result of microbial fermentation of prebiotics or probiotics within the gastrointestinal tract. These compounds subsequently exert systemic regulatory effects on host immunity, metabolism, and endocrine signaling. They are the functional output of a healthy gut ecology.
Origin
This term is a classification within microbiome science, indicating substances produced after the action of live bacteria, distinguishing them from the bacteria themselves (probiotics). They represent the functional currency derived from a healthy microbiota.
Mechanism
These metabolites, such as short-chain fatty acids, interact with host receptors throughout the body, modulating inflammatory tone and influencing hepatic lipid processing pathways. Crucially, they communicate with the gut-brain axis and can indirectly support the HPA axis set point, thereby aiding systemic hormonal equilibrium.
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