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Post-TRT HPG Axis Restart

Meaning

Post-TRT HPG Axis Restart refers to the clinical process of attempting to restore endogenous testosterone production and spermatogenesis following the cessation of exogenous Testosterone Replacement Therapy (TRT). Chronic administration of external testosterone suppresses the Hypothalamic-Pituitary-Gonadal (HPG) axis via negative feedback, rendering the testes temporarily quiescent. The restart protocol employs specific pharmaceutical agents to stimulate the hypothalamus and pituitary, thereby reactivating the body’s own hormone-producing machinery. This procedure is complex and requires careful endocrinological monitoring.