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Post TRT Fertility Signaling

Meaning

Post TRT Fertility Signaling refers to the complex neuroendocrine cascade that must be intentionally reactivated and monitored in male patients who wish to restore natural spermatogenesis and fertility following the suppressive effects of Testosterone Replacement Therapy (TRT). TRT exogenously supplies testosterone, which shuts down the Hypothalamic-Pituitary-Gonadal (HPG) axis, thereby suppressing the production of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH. Successful signaling involves therapeutic strategies to re-engage the hypothalamus and pituitary to resume pulsatile GnRH, FSH, and LH release.