Skip to main content

Post-TRT Axis Recovery

Meaning

Post-TRT Axis Recovery is the necessary clinical process of restoring the endogenous function of the Hypothalamic-Pituitary-Gonadal (HPG) axis following the cessation of exogenous Testosterone Replacement Therapy (TRT). The HPG axis is typically suppressed during TRT due to the negative feedback loop, resulting in a temporary state of secondary hypogonadism. Recovery protocols are specifically designed to stimulate the central axis—the hypothalamus and pituitary—to resume the production of Gonadotropin-Releasing Hormone (GnRH) and Luteinizing Hormone (LH), thereby restarting endogenous testosterone synthesis.