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Post-Menopause Hormones

Meaning

Post-menopause hormones refer to the characteristic pattern of circulating endocrine agents, predominantly sex steroids, observed in women who have experienced twelve consecutive months of amenorrhea following the final cessation of ovarian follicular function. The primary hormonal features include a significantly diminished production of estradiol and progesterone from the ovaries, resulting in low, stable circulating levels, while adrenal androgen production, such as DHEA and androstenedione, continues, providing necessary substrates for peripheral conversion into estrone. This specific hormonal milieu is directly responsible for the classic vasomotor symptoms, urogenital atrophy, and the accelerated bone loss and increased cardiovascular risk observed in this life stage. Clinical management often focuses on the careful consideration of hormone replacement therapy to mitigate these systemic consequences.