What is the Origin of Post-Menopausal Hormone Sequencing?

This advanced concept evolved from the traditional field of Hormone Replacement Therapy (HRT) and is rooted in the understanding of the cyclical nature of endogenous hormones. The term "sequencing" highlights the deliberate, time-dependent pattern of administration. Clinical practice recognizes that even in the post-reproductive phase, the body may benefit from rhythmic hormonal inputs.

What is the Mechanism of Post-Menopausal Hormone Sequencing?

The sequencing mechanism aims to provide the benefits of estrogen while mitigating potential risks, particularly endometrial hyperplasia, by periodically introducing progestogens to induce secretory changes or shedding. In women without a uterus, sequencing may be used to leverage the non-uterine benefits of progestogens, such as positive effects on sleep or mood, by avoiding continuous, flat-dose exposure. This strategic timing ensures a more nuanced and safer therapeutic profile.

Post-Menopausal Hormone Sequencing ∞ Area

Post-Menopausal Hormone Sequencing

Meaning

Post-Menopausal Hormone Sequencing is a specialized clinical protocol that involves the structured, cyclical, or pulsed administration of specific hormones, such as progestogens, alongside estrogen replacement therapy in women who have undergone menopause. This approach is primarily utilized to mimic the protective hormonal patterns of the pre-menopausal state or to manage endometrial health, even in the absence of a uterus, to optimize systemic benefit. It moves beyond static replacement to a more dynamic, physiological dosing schedule.