What is the Origin of Post-Cycle Support?

The practice originated in the non-clinical use of performance-enhancing drugs, but its principles are firmly rooted in established endocrinology concerning the negative feedback loops that regulate sex hormone production. Clinicians now employ structured PCS protocols to manage patients transitioning off suppressive hormonal regimens safely.

What is the Mechanism of Post-Cycle Support?

PCS typically involves the use of agents like selective estrogen receptor modulators (SERMs) or aromatase inhibitors to block estrogen's negative feedback signal at the hypothalamus and pituitary. This blockade stimulates the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). These gonadotropins then signal the testes or ovaries to resume their natural steroidogenesis, rapidly restoring the HPG axis to a functional baseline and preventing the catabolic state of prolonged hormone deficiency.

Post-Cycle Support ∞ Area

Post-Cycle Support

Meaning

Post-Cycle Support (PCS) is a clinical and pharmacological strategy involving a structured regimen of medications and supplements administered following a cycle of exogenous hormone therapy, such as anabolic androgenic steroids. The primary clinical goal of PCS is to facilitate the rapid recovery of the body’s natural, endogenous hormone production, particularly the hypothalamic-pituitary-gonadal (HPG) axis, which is suppressed by the exogenous hormones. This supportive phase is crucial for preventing prolonged hypogonadism and mitigating the adverse effects of hormone withdrawal.