What is the Origin of PLGA?

This synthetic polymer originated in materials science and has become a primary material in the development of long-acting injectable and implantable drug formulations due to its favorable degradation properties. It represents a major advancement in the pharmaceutical delivery of sensitive biological molecules, ensuring a predictable drug profile.

What is the Mechanism of PLGA?

PLGA degrades in vivo through hydrolysis of its ester bonds into its two non-toxic monomers, lactic acid and glycolic acid, which are naturally metabolized by the body. The ratio of lactic acid to glycolic acid controls the polymer's degradation rate, allowing engineers to precisely tune the drug release profile to match the desired therapeutic window for sustained hormonal therapy.

PLGA ∞ Area

PLGA

Meaning

PLGA is the acronym for Poly(lactic-co-glycolic acid), a biocompatible and biodegradable polymer widely utilized in pharmaceutical and medical device engineering, particularly for controlled drug delivery systems. Its clinical significance lies in its ability to safely encapsulate therapeutic agents, including peptide hormones, for gradual release within the body. This polymer is foundational to many long-acting hormone therapies.

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What Are the Long-Term Safety Profiles of Novel Peptide Delivery Systems?

Ensuring long-term peptide safety involves verifying the delivery system's structural integrity and biocompatibility to maintain systemic hormonal equilibrium.

HRTioAugust 2, 2025

PLGA

Meaning

Origin

Mechanism

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