What is the Origin of Platelet-Rich Plasma Therapy?

The concept originated in the field of hematology and was initially used in open-heart surgery in the 1970s to improve hemostasis. Its application expanded to maxillofacial and orthopedic surgery due to its demonstrated ability to accelerate bone and soft tissue healing. The term "Platelet-Rich Plasma" accurately describes the product, which contains a platelet concentration several times higher than baseline blood.

What is the Mechanism of Platelet-Rich Plasma Therapy?

Once injected, the concentrated platelets become activated, releasing a potent cocktail of various growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These factors bind to local cell receptors, initiating a cascade of cellular events that promote angiogenesis, cell proliferation, matrix synthesis, and tissue remodeling. This localized delivery of supra-physiological levels of growth factors is the key to its regenerative action.

Platelet-Rich Plasma Therapy ∞ Area

Platelet-Rich Plasma Therapy

Meaning

A regenerative medicine treatment that involves isolating and concentrating platelets from a patient’s own blood and then injecting this plasma into a target area, such as a joint, tendon, or skin tissue. The therapeutic effect is derived from the high concentration of growth factors and cytokines stored within the platelet alpha-granules. In the context of hormonal and aesthetic health, PRP is used to stimulate tissue repair, collagen production, and hair follicle growth. It is an autologous treatment, minimizing the risk of allergic reaction or disease transmission.