What is the Origin of Plant Sterols?

The term is derived from phyto (plant) and sterol (a class of steroid alcohols). Their discovery as biologically active compounds led to their incorporation into functional foods and supplements as a non-pharmacological means of cholesterol management. They are ubiquitous in vegetable oils, nuts, seeds, and grains.

What is the Mechanism of Plant Sterols?

Plant sterols function by competing with cholesterol for incorporation into mixed micelles within the intestinal lumen, which are essential for cholesterol absorption into the enterocytes. By displacing cholesterol, they reduce the net amount of cholesterol absorbed into the circulation. This mechanism leads to a compensatory increase in hepatic LDL receptor expression, further promoting the clearance of LDL-cholesterol from the bloodstream.

Plant Sterols ∞ Area

Plant Sterols

Meaning

Plant sterols, also known as phytosterols, are a group of steroid-like compounds naturally occurring in the cell membranes of plants, structurally resembling cholesterol. Clinically, they are recognized for their role in modulating lipid metabolism, specifically by interfering with the absorption of dietary and biliary cholesterol in the intestinal lumen. They are utilized as a dietary intervention to support a favorable serum lipid profile.