Plant Derived Hormones are therapeutic compounds that have been synthesized or extracted from botanical sources and are structurally or functionally identical to human hormones, often used in hormone replacement therapy. These include bio-identical steroids like progesterone and estradiol, which are typically synthesized from precursors found in yams or soy. Their clinical use is based on the principle that the body can recognize and utilize these molecules in the same way as endogenous hormones, offering a precise method of replenishment.
Origin
The origin lies in pharmaceutical chemistry and endocrinology, specifically the discovery and mass production of steroid hormones in the mid-20th century, notably the work of Russell Marker in converting plant sterols into progesterone. The term emphasizes the natural source of the precursor material, distinguishing them from synthetic or non-bio-identical hormone analogs.
Mechanism
The mechanism is one of direct replacement and receptor agonism. Once administered, these molecules are recognized by the body’s endocrine system due to their identical chemical structure to human hormones. They bind to the appropriate nuclear and membrane receptors in target cells, initiating the same intracellular signaling cascades and gene transcription events as the naturally produced hormones. This precise fit allows for the restoration of hormonal balance and the mitigation of deficiency symptoms.
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