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Pituitary Signaling Cascades

Meaning

The sequence of intracellular biochemical reactions initiated within the anterior or posterior pituitary gland following the binding of hypothalamic releasing or inhibiting hormones to their specific surface receptors. These cascades translate the central neuroendocrine command, often received via the portal vasculature, into the controlled secretion of tropic hormones that regulate peripheral endocrine glands. Dysregulation at this level inevitably disrupts the entire downstream axis function, leading to systemic hormonal imbalance.