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Pituitary Setpoint Recalibration

Meaning

Pituitary Setpoint Recalibration is the clinical objective of restoring the optimal sensitivity and responsiveness of the pituitary gland, the master gland of the endocrine system, particularly regarding its feedback loops. This process is often necessary when chronic stress or hormonal imbalances have caused the pituitary to adopt an inappropriate “setpoint” for hormone release, leading to systemic dysregulation. Successful recalibration is key to restoring robust hormonal rhythmicity and homeostasis across multiple axes.