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Pituitary Hypogonadism Reversal

Meaning

Pituitary hypogonadism reversal is the clinical process of therapeutically restoring the function of the hypothalamic-pituitary-gonadal (HPG) axis when the underlying cause of low sex hormone production originates from the pituitary gland or the hypothalamus. This condition, known as secondary or central hypogonadism, is characterized by low levels of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which in turn fail to stimulate the gonads. Reversal protocols aim to stimulate the pituitary to resume its normal pulsatile secretion of gonadotropins, thereby re-establishing endogenous testosterone or estrogen production and restoring fertility and vitality. This requires precise identification of the root cause, which can include functional causes like chronic stress or energy restriction.