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Pituitary Gland Feedback

Meaning

Pituitary Gland Feedback is the primary, central regulatory mechanism within the Hypothalamic-Pituitary-Thyroid (HPT) axis where the circulating concentrations of thyroid hormones, predominantly free T4 and free T3, exert a powerful negative feedback effect on the pituitary gland’s secretion of Thyroid-Stimulating Hormone (TSH). This highly sensitive and delicate mechanism ensures that TSH production is appropriately and rapidly suppressed when thyroid hormone levels are sufficient, thereby maintaining strict hormonal homeostasis. A failure or disruption of this negative feedback loop is a key clinical indicator of many different thyroid disorders.