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PINP

Meaning

PINP, or Procollagen Type I N-Terminal Propeptide, is a crucial biochemical marker utilized in clinical practice to assess the dynamic rate of bone formation. It is a non-collagenous fragment that is enzymatically cleaved from the procollagen type I molecule during the synthesis of new bone matrix by bone-forming cells called osteoblasts. Measuring the circulating level of PINP in the blood provides a quantitative and dynamic index of bone anabolism. This marker is particularly valuable for monitoring the effectiveness of anabolic therapies for osteoporosis and for evaluating overall skeletal health and bone turnover.