Pineal Peptides are a group of small, biologically active protein fragments synthesized and secreted by the pineal gland, distinct from the gland’s primary hormone, melatonin. These peptides are involved in the systemic regulation of endocrine function, the synchronization of circadian rhythms, and the modulation of immune responses. They often exhibit potent geroprotective and antioxidant effects on various tissues.
Origin
The term is derived from the ‘Pineal’ gland, a small endocrine organ located in the brain, and ‘Peptides,’ referring to their amino acid structure. Research into these non-melatonin factors, such as epithalamin and pinealon, has significantly expanded the understanding of the pineal gland’s broad regulatory and anti-aging role beyond sleep cycle control.
Mechanism
Pineal peptides function by modulating the sensitivity and responsiveness of the hypothalamus and pituitary gland to releasing hormones, thereby influencing the entire neuroendocrine cascade. Their action helps to synchronize the body’s hormonal milieu with environmental cues and promotes robust cellular antioxidant defense. This systemic regulation supports the integrity of the endocrine system and plays a role in regulating aging processes.
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