What is the Origin of PI3K?

The term is an acronym for the enzyme's biochemical function: the phosphorylation of the 3-hydroxyl group of the inositol ring in phosphatidylinositol lipids. Its discovery in the late 1980s as a target of oncogenic viruses established its importance in cell biology. In endocrinology, the pathway gained prominence for mediating the anabolic and anti-apoptotic effects of insulin and IGF-1.

What is the Mechanism of PI3K?

The mechanism of action begins when an extracellular signal, such as insulin or a growth factor, binds to its receptor on the cell surface, activating the receptor's tyrosine kinase domain. This activation recruits and activates PI3K, which then phosphorylates the lipid phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 acts as a second messenger, recruiting and activating downstream kinases like Akt (Protein Kinase B), which then orchestrates the final physiological responses, such as glucose uptake and protein synthesis.

PI3K

Meaning

PI3K, or Phosphatidylinositol 3-kinase, is a critical family of intracellular signaling enzymes that plays a pivotal role in regulating fundamental cellular functions, including growth, proliferation, differentiation, motility, and survival. As a central node in numerous hormonal and growth factor signaling pathways, it is a key regulator of metabolic health, including insulin sensitivity and cellular anabolism. Dysregulation of the PI3K pathway is frequently implicated in metabolic disorders and carcinogenesis.

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PI3K

Meaning

Origin

Mechanism

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