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PI-3K/Akt Pathway

Meaning

The Phosphoinositide 3-kinase (PI-3K)/Akt pathway is a pivotal intracellular signaling cascade that regulates numerous fundamental cellular functions, including metabolism, proliferation, survival, and protein synthesis. This pathway is a major transducer of signals from various growth factors and hormones, such as insulin and IGF-1, making it a central nexus in hormonal health and disease. Dysregulation of this cascade is implicated in conditions ranging from insulin resistance to various forms of cancer. It is a master regulator of anabolic and survival signals.