Physique Cognitive Dominance describes a synergistic state where optimized physical health, particularly high-quality muscle mass and low systemic inflammation, directly contributes to and enhances superior cognitive function and mental resilience. This concept highlights the crucial, bidirectional link between the muscle-derived myokine signaling (the “physique” component) and the brain’s capacity for executive function, mood stability, and neuroplasticity (the “cognitive dominance” component). Achieving this dominance signifies a highly optimized neuro-muscular-endocrine integration.
Origin
This is a translational, conceptual term used in longevity and performance optimization, combining ‘physique’ (body structure), ‘cognitive’ (mental process), and ‘dominance’ to express the synergistic superiority of their integrated function. It is rooted in the modern understanding of muscle as an endocrine organ that communicates with the brain via the myokine cascade.
Mechanism
The mechanism is mediated by myokines, such as Brain-Derived Neurotrophic Factor (BDNF) and cathepsin B, which are released from contracting muscle and cross the blood-brain barrier. These factors promote hippocampal neurogenesis, enhance synaptic plasticity, and exert anti-inflammatory effects within the central nervous system. A robust physique, therefore, acts as a systemic anti-inflammatory reservoir, directly supporting the metabolic and structural integrity of the brain, thereby facilitating superior cognitive performance and resilience against neurodegeneration.
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